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Prof. Dr. Helmut Friess, (Key person 1): Chairman, Department of Surgery; expertise in high-throughput analysis, randomized controlled clinical studies

Dr. Jörg Kleeff (Key person 2): Surgeon; expertise in high-throughput analysis, tissues collection/archiving, randomized controlled clinical studies
Dr. Christoph W. Michalski: Surgical resident and postdoctoral research fellow with experience in tissue collection/archiving, database management, randomized controlled clinical studies


Research Focus
The Department of General Surgery at the Technische Universität München, Munich, Germany is one of the leading centers for pancreatic surgery and clinical as well as basic research in Europe. Tissue and serum samples are routinely obtained from pancreatic cancer patients following written informed consent. All studies have been approved by the local Ethics Committee and are carried out according to the current version of the Declaration of Helsinki (1996). The tissue and serum bank at the Department of Surgery comprises more than 500 well documented cases of pancreatic tumours. The molecular biology research laboratory as part of the Department of General Surgery has a renowned track record of pancreatic research. High throughput analysis such as DNA microarrays have been employed for the detection of diagnostic tools and/or molecular targets in pancreatic diseases. Having one of the largest collections of high quality tissue specimen, candidate genes are currently being investigated on a broad scale (see relevant publications). Parts of the studies are conducted in close collaborations with partners at the GSF - National Research Center for Environment and Health (www.gsf.de) and at the German Cancer Research Center, Heidelberg (DKFZ, www.dkfz.de). In addition, a clinical trial centre (Chir-Net) has been established at the Department of General Surgery with full-time working physicians, study nurses and secretaries. This infrastructure allows for the rapid clinical testing of new diagnostic and therapeutic modalities in pancreatic cancer.