Welcome to MolDiag-PaCa


Prof. Dr. Jörg Rademann
Head of Medicinal Chemistry

Dr. Jens Peter von Kries
Head of Screening Unit


Research Profile
The group identifies and optimizes small molecules as specific biological effectors for studying protein structure, protein function and as potential starting points for pharmacological intervention. By doing so, the group enables the translation of biological knowledge gained in the areas of structure biology and cell biology into pharmacologically relevant small molecules.
For this purpose, we develop strategies in the areas of synthetic organic chemistry, library design, and bioassays. Most protein targets of the group are disease-related enzymes including proteases and phosphatases relevant to clinical indications including cancer, Alzheimer, tuberculosis, and SARS. Recently, the targeted proteins have been extended towards receptors and protein-protein interactions.
The FMP screening unit serves infrastructure for high to moderate throughput searches in screening libraries containing about 40.000 compounds. Supported screening technologies are based on fluorescence intensity, fluorescence polarization, luminescence and absorption measurements with different microplate readers using 384-well plates. Furthermore a new screening technology using an automated microscope for identification of compounds which affect cellular localisation of proteins in living cells will be established in 2007. The unit has set up and finished about 30 screening projects in the BMBF funded Mycobacterium tuberculosis consortium and supported about 10 guest projects since 2004.


Contribution to the Consortium
Identification and development of specific small molecules targeting pancreas-cancer related proteins as potential imaging probes for the early diagnosis of pancreas cancer.


Group members involved:
  • Sina Meyer
  • Christoph Erdmann
  • Marco Schmidt
  • Viviane Uryga-Polowy
  • Dr. Samuel Beligny

Contact:
Prof. Dr. Jörg Rademann & Dr. Jens Peter von Kries
Leibniz-Insitut für Molekulare Pharmakologie, FMP
Robert-Rössle-Str. 10
13125 Berlin
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