Welcome to MolDiag-PaCa

Malignant tumours of the pancreas, known as pancreatic carcinomas, remain among the most serious challenges in modern medicine. Although not among the most common tumours, they are among the most frequent causes of cancer-related deaths, with approximately 28,000 deaths per year in the USA (3) and 40,000 per year in Europe (13). There are currently no means for the reliable diagnosis of early stages and for curative treatment of late stages of the tumour.

The overall aim of this EU Framework Programme 6 Integrated Project is to make use of genetic profiles of pancreatic cancer and precursor lesions to improve the outcome of pancreatic cancer patients by providing novel and highly efficient molecular diagnostic tools. One of the major prerequisites in order to achieve this ambitious aim is an integrated multidisciplinary research approach, which enables a strong interaction between technology, biology and medicine to translate genome data into practical, clinical applications.

in cooperation with the DiMI / EMIL Summer School 2008 �Cardiovascular Applications of Molecular Imaging�

The Molecular Imaging Workshop within the MolDiag-Paca network took place at the University Hospital Muenster, Monday 1st September 2008.
The course was attended by 21 clinicians/scientists interested in molecular imaging techniques/modalities. The contents spanned everything from clinically relevant imaging approaches (e.g. MRI, CT, PET) to pre-clinical/basic research imaging platforms like fluorescence mediated tomography (FMT) or fluorescence reflectance imaging (FRI). Another topic focused on probe design and molecular imaging applications for in vivo drug screening, which offered an deeper insight of the multidisciplinary interaction in this new and rapidly growing research discipline.

The course covered the following program:

  • FRI/FMT � principles of operation and molecular imaging � Jens Waldeck, Münster
    (in parallel at the Summer School: Basic Physiology of the Cardiovascular System, Ulrich Decking, Düsseldorf)
  • PET � principles of operation and molecular imaging � Lars Stegger, Münster
  • Ultrasound/echo � principles of operation and molecular imaging � Georg Schmitz, Bochum
  • CT � principles of operation � Stefan Käpplinger, Erlangen
  • MRI � principles of operation and molecular imaging � Cornelius Faber, Würzburg/Münster
  • Molecular imaging for in vivo drug screening � Normann Koglin, Berlin
    (in parallel at the Summer School: Co-registration of moving structures (heart, vessels ...), Klaus Schäfers, Münster)
  • The chemistry behind tracers � Carsten Höltke, Münster
  • Pitfalls in Tracer development and imaging � Christoph Bremer, Münster
    (in parallel at the Summer School: Meet the experts � open discussion, all speaker)
  • Lab-Tour (FRI/FMT/3T MRT) � Bremer/Waldeck, Münster

  • MolDiag-Paca Consortium: "A Pancreas Cancer Research Celebration" CNIO Madrid,
    June 8th 2009, 16-19:30
    We desperately need to make progress towards reducing pancreas cancer mortality. Recent advances in mouse models of the disease, the genetic factors involved in its development, and in the treatment of patients with respectable tumours are paving the way to making such progress
  • WORKSHOP: Epidemiology and its application to pancreatic cancer.
    On Feb 5 a MolDiagPaca workshop on epidemiology and its application to pancreatic cancer will be held at CNIO in Madrid, Spain. Renowned speakers will present on basic principles of epidemiology, and give an overview of genetic epidemiology, environmental and genetic factors of pancreatic cancer, including possible susceptibility genes in sporadic disease vs. familial disease. The magnitude of the disease will be presented and etiological factors and somatic genetic alterations in pancreas cancer will be addressed. Finally, future directions in pancreatic cancer research will be outlined.
  • Executive Summary of our second annual report with MolDiagPaca accomplishments during its second year
  • MolDiag-Paca Workshop "Molecular Imaging"
    University Hospital Muenster, 1st September 2008
  • The Teaching course on the pathology of pancreatic tumors is now in the internet! Please click here to access the e-learning course.
  • Executive Summary of our first annual report with MolDiagPaca accomplishments during its first year
  • The Clinical course on pancreatic cancer within the MolDiagPaCa network took place at the Karolinska University Hospital in Stockholm, Sweden on November 23, 2007. The course was especially adapted to the needs of non-clinical pancreatic cancer researchers and as a refreshment course for clinicians.
  • The Teaching course on the pathology of pancreatic tumors took place in Verona, on May 18th 2007 with 88 participants, 34 of which were not directly involved with MolDiagPaca: In the last few years, new concepts regarding the histological and molecular subclassification of exocrine pancreatic tumors have been established.
  • The MolTools - DKFZ - IGB - MolDiagPaca Practical Course: Analysis and Interpretation of Complex Transcript Data took place at DKFZ in Heidelberg during the period Thursday, 14 December, to Saturday, 16 December 2006. In total 16 scientists of different European countries participated.